Plenary 1 & Featured Abstract Chair: Eva-Maria Krämer-Albers Co-Chair: Andreas Möller
09:00 – 09:45 CET
Plenary 1: Converging EV, LNP, and virus biology; towards oral RNA Drugs
Location: Plenary - Hall C
Presenter: Nicole Meisner-Kober – Ludwig Boltzmann Institute for Nanovesicular Precision Medicine, Paris Lodron University of Salzburg, Austria
09:45 – 10:00 CET
Featured Abstract: Development of membrane fusion engineered extracellular vesicles as antigen presentation carriers to improve the efficacy of HER2 antibody-drug conjugates
Location: Plenary - Hall C
Presenting Author: Shili Yao, n/a – School of Materials Science and Engineering, Faculty of Medicine, Tianjin University
Disease and therapy
10:00 – 10:30 CET
Coffee Break
10:00 – 10:30 CET
Coffee Break
10:30 – 12:00 CET
OT01 EV Biomarkers 1 Chair: Franz Ricklefs Co-Chair: Sara Veiga
10:30 – 11:00 CET
OT01.0 - Liquid Biopsy for CNS Tumors Using Tumor-secreted EVs
Location: Strauss 2
Presenter: Franz Lennard. Ricklefs – 7. Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Disease and therapy
11:00 – 11:15 CET
OT01.1 - Longitudinal monitoring of glioblastoma sEV evolution using a nanodiagnostic to detect emergence of glioma stem cells driving recurrent disease
Location: Strauss 2
Presenting Author: Zhen Zhang, n/a – The University of Queensland Australian Institute for Bioengineering and Nanotechnology
Disease and therapy
11:15 – 11:30 CET
OT01.2 - From challenge to opportunity: a methodology to measure reproducible EV concentrations
OT01.3 - Plasma extracellular vesicle-associated protease activity as a technically robust functional biomarker for uveal melanoma treatment response
Location: Strauss 2
Presenting Author: Jan Van Deun, PhD – Universitätsklinikum Erlangen
Disease and therapy
11:45 – 12:00 CET
OT01.4 - Unveiling neuroblastoma: characterizing the proteome and surface markers of extracellular vesicle to discover new biomarkers and elucidate premetastatic niche formation
Location: Strauss 2
Presenting Author: Martin Auber, n/a – Charité – University Medicine Berlin
Disease and therapy
10:30 – 12:00 CET
OT02 Mechanisms of EV Biogenesis Chair: Guillaume van Niel Co-Chair: Cristóbal Cerda-Troncoso
10:30 – 11:00 CET
OT02.0 - The winding road of CD63
Location: Lehar 3-4
Presenter: Guillaume van Niel – INSERM U1307 CRCI²NA - Nantes - Angers Cancer and Immunology Research Center - Team 3 EVICAT,
EV sources and basic biology
11:00 – 11:15 CET
OT02.1 - RalA/B cooperate with EHD4 to shape multi-vesicular bodies for tumor EVs secretion
OT03.3 - Translocation and implication for disease pathogenesis of bacterial extracellular vesicles from gut commensal pathobiont Klebsiella pneumoniae in distant organs
OT04.1 - Extracellular Vesicle Online Knowledge Explorer (EVOKE) - A guiding tool for the selection of extracellular vesicles preparation methods
Location: Strauss 1
Presenting Author: Claudio A. Pinheiro – Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium
Technologies and methods
11:15 – 11:30 CET
OT04.2 - Selective enrichment of circulating cardiac-derived extracellular vesicles for disease monitoring
Sponsor lunch: Beckman Coulter Title: Harnessing the CytoFLEX nano for Extracellular Vesicle and Nanoparticle Analysis Speaker: Dr. Joshua Price, PhD, University of Birmingham, Department of Inflammation and Ageing
12:30 – 13:30 CET
Sponsor lunch: Beckman Coulter Title: Harnessing the CytoFLEX nano for Extracellular Vesicle and Nanoparticle Analysis Speaker: Dr. Joshua Price, PhD, University of Birmingham, Department of Inflammation and Ageing
OT05 EV Therapeutics Development Chair: Bernd Giebel Co-Chair: Alexander Otahal
14:30 – 15:00 CET
OT05.0 - MSC-EVs: Unlocking Clinical Potential and Overcoming Translational Challenges
Location: Strauss 2
Presenter: Bernd Giebel, Prof – Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Disease and therapy
15:00 – 15:15 CET
OT05.1 - Dual-function extracellular vesicles for mRNA and enzyme co-delivery in Fabry disease therapy
Location: Strauss 2
Presenting Author: Sin-Yu Chen, n/a – Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Disease and therapy
15:15 – 15:30 CET
OT05.2 - Enhanced delivery of RNA therapeutics via extracellular vesicles for targeted treatment of peritoneal and lung metastases
Location: Strauss 2
Presenting Author: Tram TT Nguyen, n/a – Yong Loo Lin School of Medicine, National University of Singapore
Disease and therapy
15:30 – 15:45 CET
OT05.3 - RNA-based therapies by red blood cell-derived extracellular vesicle mimetics: a new platform for the development of easily translatable and scalable therapeutics for chronic and metabolic diseases
Location: Strauss 2
Presenting Author: Sara Biagiotti – Department of Biomolecular Sciences, University of Urbino Carlo Bo
Disease and therapy
15:45 – 16:00 CET
OT05.4 - An engineered siRNA backbone improves siRNA delivery via extracellular vesicles
OT06.4 - Decoding de novo synthetized proteins in the polarized macrophage´s soluble and EV-enclosed secretomes and their uptake into fibroblasts
Location: Strauss 1
Presenting Author: Ulrike Resch, n/a – Center for Physiology and Pharmacology (Institute of Vascular Biology and Thrombosis Research), Medical University of Vienna
EV sources and basic biology
14:30 – 16:00 CET
OT07 Tissue Homeostasis Chair: Stefan Momma Co-Chair: Seiko Matsuo
14:30 – 15:00 CET
OT07.0 - Preserving Quiescence: Multidrug Transporter-Driven EV Release in Stem Cell Homeostasis
OT07.3 - Podocyte exopher-formation in membranous nephropathy
Location: Lehar 3-4
Presenting Author: Karen Lahme, n/a (she/her/hers) – Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, Hamburg
Physiology and pathology
15:45 – 16:00 CET
OT07.4 - Intra-nephron cross talk through exosomes
OT08.1 - Squeezable Hydrogel Microparticles for Single Extracellular Vesicle Protein Profiling
Location: Lehar 1-2
Presenting Author: Jina Ko, n/a – University of Pennsylvania
Technologies and methods
15:15 – 15:30 CET
OT08.2 - Single Extracellular VEsicle Nanoscopy-Universal Protocol (SEVEN-UP): accessible imaging platform for quantitative characterization of single extracellular vesicles
Location: Lehar 1-2
Presenting Author: Tijana Jovanovic-Talisman (she/her/hers) – Department of Cancer Biology and Molecular Medicine, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, California 91010, United States.
Technologies and methods
15:30 – 15:45 CET
OT08.3 - Mapping single extracellular vesicle landscapes to dissect tumour heterogeneity and evolution of drug resistance in glioblastoma
Location: Lehar 1-2
Presenting Author: Mahsa Jalali, n/a – Research Institute of McGill University Health Center (RI-MUHC)
Technologies and methods
15:45 – 16:00 CET
OT08.4 - Single vesicle-resolved lipidomics of extracellular vesicles via mass spectrometry imaging to untangle the EV interactome in ovarian cancer
Location: Lehar 1-2
Presenting Author: Randy P. Carney – University of California, Davis
Technologies and methods
16:00 – 16:30 CET
Break
16:00 – 16:30 CET
Break
16:30 – 17:30 CET
Mixed Format: SNEV Meet the EV-experts Session I: Fundamental and Physiology
16:30 – 17:30 CET
Mixed Format: SNEV Meet the EV-experts Session I: Fundamental and Physiology
Location: Stolz 2
Moderator: Cristóbal A. Cerda-Troncoso – Laboratory for extracellular vesicles research, Department of human genetics, KU Leuven, Leuven, Belgium
16:30 – 17:30 CET
Mixed Format: ISEV Committee Translation, Regulation and Advocacy (TRA) "Bridging the gap between basic, industry and clinical science: limitations and solutions“
16:30 – 17:30 CET
Mixed Format: ISEV Committee Translation, Regulation and Advocacy (TRA) "Bridging the gap between basic, industry and clinical science: limitations and solutions“
Moderator: Rossella Crescitelli (she/her/hers) – Sahlgrenska Center for Cancer Research and Wallenberg Centre for Molecular and Translational Medicine, Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
