.jpg "Cristina Grange, n/a photo")
Senior Researcher
Department of Medical Sciences, University of Turin, Italy, Italy
Cristina Grange, phD, Department of Medical Sciences, University of Turin, Italy. In 2004 I graduated in Medical Biotechnology at the University of Turin (110/110 cum laude) with a thesis entiteld "Identification and characterization of human resident stem cell derived from adult kidney (coordinator Professor Giovanni Camussi). In 2007 I obtained my phD in Medical Pathophysiology at the University of Turin; thesis’ title: Endothelial differentiation of human mammary tumor stem cells (coordinator Professor Giovanni Camussi).
I have a biotechnology background, and my research field is renal regeneration upon damage. I am investigating the role of extracellular vesicles released by different stem cell sources in models of chronic kidney disease such as diabetic nephropathy and the role extracellular vesicles isolated from urine of healthy subjects in models of AKI. I reached strong experience on pre-clinical animal model to test new therapeutic strategies for regenerative medicine and on in vivo imaging.
Recently, I am involved in many projects with the aim to evaluate the effect of extracellular vesicle released from stem cells in several experimental models of renal damage, and to monitor their bio-distribution by Optical Imaging in vivo. We published several papers demonstrating the regenerative effect of extracellular vesicles shed by MSCs in preclinical model of on acute kidney injury (AKI) induced by glycerol or cisplatin injections or by ischemia.