Research Director, Team leader
INSERM U1307 CRCI²NA - Nantes - Angers Cancer and Immunology Research Center - Team 3 EVICAT,
Guillaume van Niel (research director) is a cell biologist leading the team “endosomal dynamic in neuropathies” at the Institute of Psychiatry and Neurosciences of Paris (IPNP), France. G. van Niel has contributed for 20 years to the understanding of the biogenesis and function of exosomes from various cell types, their role in physiological amyloid formation and its contribution to live tracking of EVs in vitro and in vivo. His recent work has used cutting edge imaging methods (in vivo live imaging, CLEM) to establish new approaches to tackle the molecular mechanisms that regulate exosome secretion. He has developed the first vertebrate model in zebrafish to live track endogenous exosome at the single vesicle scale from their site of production up to their final destination in the whole organism. His current research project aims at better understading the molecular regulation of exosome secretion from endosomes, at exploring the relevance of exosomes and the endolysosomal system in Alzheimer’s Disease and Glioblastoma progression.