Laboratory of Experimental Cancer Research, Ghent University, Ghent, Belgium
Ghent, Oost-Vlaanderen, Belgium
Lien Lippens, PhD student, Ghent University, Belgium
In October 2016 I started my PhD research at the Laboratory of Experimental Cancer Research under the supervision of prof. An Hendrix. During my master thesis as well as during the first few years of my PhD I actively contributed to the optimization of EV separation and characterisation protocols (Van Deun et al., Nat Methods, 2017; Geeurickx et al., Nat Commun, 2019; Tulkens et al., Gut, 2020; Dhondt et al., JEV, 2020). Besides I also investigated the biomarker potential of tumor infiltrating lymphocytes in cervical tumor tissue (Lippens et al., IJC, 2020). Currently I am investigating EV biomarker potential in blood plasma of cervical and endometrial cancer patients. Can EV numbers, EV protein cargo and/or RNA present in EVs be used to predict response to therapy or survival of patients with gynaecological tumors? Besides the investigation of biomarker potential of EVs we are also investigating fast, cheaper and more reproducible methods of detecting EVs in patient plasma. This is the point asymmetrical flow field-flow fractionation (AF4) comes into the picture. We believe the AF4 could circumvent some problems currently present in EV research and could potentially lead to implementation of EV biomarkers in the clinic.
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Friday, April 25, 2025
09:00 – 09:15 CET